AIF-1 GENE AS STRONG PROGNOSTIC BIOMARKER FOR ORAL CANCER

Objective: Oral Squamous Cell Carcinoma (OSCC), which is the sixth most prevalent type of cancer across globe caused by cigarette smoking, smokeless tobacco use, excessive and extreme alcohol oral trauma, HPV (Human Papilloma Virus) infection as well genetic mutations. AIF-1(Allograft Inflammatory Factor) has been identified an inflammatory response modulator, its increased expression linked to carcinogenesis. Methods: In this study, 200 OSCC patients matched controls were compared investigate if there was any association between gene risk cavity in North Indian population. polymorphism rs2857595 detected using TaqMan probe assay. Results: The findings our study revealed that AA genotype Gene increases susceptibility Carcinoma. with more co-dominant model combination both mutant genotypes (AA+AG) significantly associated recessive model. GG AIF-1 (Allograft comes out a protective effect against (OSCC Carcinoma). To further understand role polymorphism, we various clinicopathological characteristics patients. And found have higher developing high-grade tumors nodal involvement. Conclusion: Thus, locus can be considered important point development accurate preventive approach prognostic indicator for cancer.